ABSTRACT
Objective :To explore influence of Naoxintong capsule on vascular endothelial function and hemorheology in patients with coronary heart disease (CHD) and hyperlipidemia .Methods :A total of 112 CHD patients with hy‐perlipidemia were equally divided into routine treatment group (received routine western medicine treatment ) and Naoxintong group (received Naoxintong capsule based on routine treatment group ).Therapeutic effect ,vascular en‐dothelial function and hemorheological indexes before and after treatment were compared between two groups .Re‐sults :After treatment ,total effective rate of Naoxintong group was significantly higher than that of routine treat‐ment group (94. 64% vs.76.78%, P＝0. 025).Compared with routine treatment group after treatment ,there were significant rise in serum levels of nitric oxide (NO) [ (36. 36 ± 0.43) μmol／L vs.(43. 78 ± 0.72) μmol／L] and nitric oxide synthetase (NOS) [(16. 48 ± 0.78) U／L vs.(30. 25 ± 0. 93) U／L] ,and significant reductions in serum levels of von Willebrand factor (vWF) [ (146.37 ± 0.66)% vs.(132.71 ± 0.85)%] and endothelin‐1 (ET‐1) [ (7. 17 ± 0. 41) ng／ml vs .(5. 40 ± 0.50) ng／ml] , P＝0.001 all ;significant reductions in levels of whole blood low shear viscosity [ (12.28 ± 0.55) mPa·s vs.(9. 17 ± 0.44) mPa·s] ,whole blood high shear viscosity [ (5.38 ± 0.39) mPa·s vs. (4.61 ± 0. 43) mPa·s] ,plasma viscosity [(2. 00 ± 0.17) mPa·s vs.(1.53 ± 0.11) mPa·s] and hematocrit [(45. 61 ± 0.59)% vs.(41. 13 ± 0.53)%] in Naoxintong group , P＝0. 001 all.Conclusion :Naoxintong capsule based on rou‐tine treatment can significantly improve vascular endothelial function and hemorheological indexes in CHD patients with hyperlipidemia .
ABSTRACT
The inflammatory reaction is the important pathologic foundation of growth and development of many diseases. Previously, anti-pathogen is the chief treating principle on infectious diseases, while anti-inflammation is the supplementary one. With the deep-going investigation on the effect of inflammatory reaction in the pathological process of severe infectious diseases in recent decade, especially the advance of concept on systemic inflammatory reaction syndrome (SIRS), anti-inflammatory treatment has become the vital link for comprehensive intervention therapy of severe infectious disease. Close correlation is also presented between numerous non-infectious diseases with systemic inflammatory reaction, e.g., atherosclerosis is one kind of inflammatory reaction, there are effects of many inflammatory factors on the metabolic process in patients with obesity. The regulation of Chinese herbs on inflammatory reaction may be one of the well cut-in points of integrative Chinese and Western medical study of anti-inflammation.